{"id":17572,"date":"2020-09-20T20:15:02","date_gmt":"2020-09-20T20:15:02","guid":{"rendered":"https:\/\/reproduccionbilbao.es\/?p=17572"},"modified":"2026-04-15T11:55:42","modified_gmt":"2026-04-15T11:55:42","slug":"sindrome-antifosfolipidico-sap","status":"publish","type":"post","link":"https:\/\/reproduccionbilbao.es\/fr\/sindrome-antifosfolipidico-sap\/","title":{"rendered":"\u00bfQu\u00e9 es el S\u00edndrome antifosfolip\u00eddico (SAP)?"},"content":{"rendered":"<p>Por <a href=\"https:\/\/reproduccionbilbao.es\/gorka-barrenetxea-ziarrusta\/\" target=\"_blank\" rel=\"noopener noreferrer\"><strong><u>Dr. Gorka Barrenetxea<\/u><\/strong><\/a> (Director de Reproducci\u00f3n Bilbao)<\/p>\n<p>Las enfermedades autoinmunes se caracterizan porque el organismo genera anticuerpos contra c\u00e9lulas o elementos del propio cuerpo. Se tratar\u00eda, en cierto modo, de una \u201cautoagresi\u00f3n\u201d. Los efectos de tales autoanticuerpos pueden ser muy variados e incluyen, tambi\u00e9n, trastornos reproductivos.<\/p>\n<p>Aunque ya desde la primera mitad del siglo XX se reconoci\u00f3 que algunos anticuerpos antifosfolip\u00eddicos (APL) caracter\u00edsticos de ciertas enfermedades autoinmunes ya conocidas, como el lupus eritematoso sist\u00e9mico (LES), se asociaban a cuadros de trombosis arteriales y venosas, abortos de repetici\u00f3n y p\u00e9rdidas fetales, no fue hasta la d\u00e9cada de los 80 cuando se defini\u00f3 el llamado <strong>s\u00edndrome antifosfolip\u00eddico (SAP)<\/strong> como una entidad con rasgos cl\u00ednicos y anal\u00edticos determinados e independientes de otras entidades autoinmunes.<\/p>\n<p>El t\u00e9rmino SAP fue inicialmente definido en 1986, alcanz\u00e1ndose un consenso universalmente aceptado en 1999 como la asociaci\u00f3n de cuadros de trombosis (arteriales y venosas), complicaciones obst\u00e9tricas (fundamentalmente <strong>abortos de repetici\u00f3n<\/strong> y <strong>p\u00e9rdidas fetales<\/strong> <strong>recurrentes<\/strong>) con par\u00e1metros anal\u00edticos como la presencia de anticuerpos antifosfolip\u00eddicos (APL) y\/ anticuerpos anticardiolipina (ACA) junto con alteraciones hematol\u00f3gicas (anemia y trombocitopenia).<\/p>\n<p>Lo cierto es que, a pesar de los m\u00faltiples estudios realizados, se desconoce la etiopatogenia del cuadro: esto es, se desconoce el mecanismo por el que los mencionados anticuerpos provocan las p\u00e9rdidas fetales. Aunque ciertamente, parece que un fen\u00f3meno de coagulaci\u00f3n (trombosis) puede estar en la base del problema.<\/p>\n<p>En definitiva, las pacientes embarazadas afectas de un SAP est\u00e1n en riesgo de sufrir abortos de repetici\u00f3n y perdidas fetales tard\u00edas recurrentes. Por tanto, es preceptivo que en estas pacientes se descarte este s\u00edndrome, determinando la posible presencia de APL o ACA. Descartadas otras causas de abortos, y diagnosticado un cuadro de SAP el tratamiento se basar\u00e1, fundamentalmente, en medicaciones con efecto antiagregante (\u00e1cido acetil-salic\u00edlico) y\/o anticoagulante (Heparina).<\/p>\n<p>Para una profundizaci\u00f3n del tema recomendamos el libro <strong><em>\u201cFactores inmunol\u00f3gicos implicados en los abortos de repetici\u00f3n\u201d <\/em><\/strong>(<u>https:\/\/ehu.on.worldcat.org\/oclc\/434002791<\/u>)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Por Dr. Gorka Barrenetxea (Director de Reproducci\u00f3n Bilbao) Las enfermedades autoinmunes se caracterizan porque el organismo genera anticuerpos contra c\u00e9lulas o elementos del propio cuerpo. Se tratar\u00eda, en cierto modo, de una \u201cautoagresi\u00f3n\u201d. Los efectos de tales autoanticuerpos pueden ser muy variados e incluyen, tambi\u00e9n, trastornos reproductivos. Aunque ya desde la primera mitad del siglo <\/p>\n<div class=\"btn-more-wrapper\"><a href=\"https:\/\/reproduccionbilbao.es\/fr\/sindrome-antifosfolipidico-sap\/\" class=\"btn btn-sm btn-hover-fill\"><svg class=\"icon icon-right-arrow\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\"><title>right-arrow<\/title><path d=\"M21.548 5.088c-0.436-0.451-1.162-0.451-1.613 0-0.436 0.436-0.436 1.162 0 1.596l8.177 8.177h-26.984c-0.629 0.001-1.129 0.501-1.129 1.13s0.5 1.145 1.129 1.145h26.984l-8.177 8.162c-0.436 0.451-0.436 1.178 0 1.613 0.451 0.451 1.178 0.451 1.613 0l10.113-10.113c0.451-0.436 0.451-1.162 0-1.596l-10.113-10.114z\"><\/path><\/svg>Read More<span class=\"screen-reader-text\"> \u00ab\u00a0\u00bfQu\u00e9 es el S\u00edndrome antifosfolip\u00eddico (SAP)?\u00a0\u00bb<\/span><svg class=\"icon icon-right-arrow\" version=\"1.1\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"32\" height=\"32\" viewBox=\"0 0 32 32\"><title>right-arrow<\/title><path d=\"M21.548 5.088c-0.436-0.451-1.162-0.451-1.613 0-0.436 0.436-0.436 1.162 0 1.596l8.177 8.177h-26.984c-0.629 0.001-1.129 0.501-1.129 1.13s0.5 1.145 1.129 1.145h26.984l-8.177 8.162c-0.436 0.451-0.436 1.178 0 1.613 0.451 0.451 1.178 0.451 1.613 0l10.113-10.113c0.451-0.436 0.451-1.162 0-1.596l-10.113-10.114z\"><\/path><\/svg><\/a><\/div>\n","protected":false},"author":6,"featured_media":17573,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[66],"tags":[],"class_list":["post-17572","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-reproduccion-asistida"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u00bfQu\u00e9 es el S\u00edndrome antifosfolip\u00eddico (SAP)? - Reproducci\u00f3n Bilbao<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/reproduccionbilbao.es\/sindrome-antifosfolipidico-sap\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00bfQu\u00e9 es el S\u00edndrome antifosfolip\u00eddico (SAP)? - Reproducci\u00f3n Bilbao\" \/>\n<meta property=\"og:description\" content=\"Por Dr. Gorka Barrenetxea (Director de Reproducci\u00f3n Bilbao) Las enfermedades autoinmunes se caracterizan porque el organismo genera anticuerpos contra c\u00e9lulas o elementos del propio cuerpo. Se tratar\u00eda, en cierto modo, de una \u201cautoagresi\u00f3n\u201d. Los efectos de tales autoanticuerpos pueden ser muy variados e incluyen, tambi\u00e9n, trastornos reproductivos. 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Se tratar\u00eda, en cierto modo, de una \u201cautoagresi\u00f3n\u201d. Los efectos de tales autoanticuerpos pueden ser muy variados e incluyen, tambi\u00e9n, trastornos reproductivos. 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